below this sort of conditions, observed substitutions involving genomes approximate a random sample with the mutations that have occurred. due to this, when selection is calm, biases from the designs of substitutions observed in between genomes will improved approximate mutational biases.

We investigated the co-occurrence and exclusivity of mutations in the same cancer gene pairs across all most cancers types. Curiously, we observed that selected gene pairs show unique mutation designs in several cancer sorts. As an example, we observed that mutations while in the TP53 As

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